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    New roles for acyl-CoA-binding proteins (ACBPs) in plant development, stress responses and lipid metabolism

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    Abstract
    ACBPs are implicated in acyl-CoA trafficking in many eukaryotes and some prokaryotes. Six genes encode proteins designated as AtACBP1–AtACBP6 in the Arabidopsis thaliana ACBP family. These ACBPs are conserved in the acyl-CoA-binding domain, but vary in size from 92 amino acids (10.4 kDa) to 668 amino acids (73.1 kDa), and are subcellularly localised to different compartments in plant cells. Results from in vitro binding assays show that their corresponding recombinant proteins exhibit differential binding affinities to acyl-CoA esters and phospholipids, implying that these ACBPs may have non-redundant biological functions in vivo. By using knockout/downregulated and overexpression lines of Arabidopsis ACBPs, recent investigations have revealed that in addition to their proposed roles in phospholipid metabolism, these ACBPs can influence plant development including early embryogenesis and leaf senescence, as well as plant stress responses including heavy metal resistance, oxidative stress, freezing tolerance and pathogen resistance. In this review, recent progress on the biochemical and functional analyses of Arabidopsis ACBPs, their links to metabolic/signalling pathways, and their potential applications in development of stress tolerance are discussed.Article Outline
    1. Introduction
    2. Plant acyl-CoA-binding proteins
    3. Arabidopsis acyl-CoA-binding proteins and their protein interactors
    3.1. Membrane-associated acyl-CoA-binding proteins AtACBP1 and AtACBP2
    3.2. Apoplastic acyl-CoA-binding protein AtACBP3
    3.3. Cytosolic acyl-CoA-binding proteins AtACBP4 and AtACBP5
    3.4. Small 10-kDa acyl-CoA-binding potein AtACBP6
    3.5. Proteins interactors of Arabidopsis acyl-CoA-binding proteins
    4. Role of Arabidopsis acyl-CoA-binding proteins in plant development
    4.1. Acyl-CoA-binding proteins in embryo development
    4.2. Acyl-CoA-binding protein in leaf senescence
    5. Role of Arabidopsis acyl-CoA-binding proteins in stress responses
    5.1. Acyl-CoA-binding proteins in heavy metal resistance and oxidative stress
    5.2. Acyl-CoA-binding proteins in freezing tolerance
    5.3. Acyl-CoA-binding proteins in pathogen resistance
    6. Role of Arabidopsis acyl-CoA-binding proteins in lipid metabolism
    6.1. Binding affinities of acyl-CoA-binding proteins to acyl-CoA esters and phospholipids
    6.2. Molecular and biochemical characterisation of lines downregulated and overexpressing acyl-CoA-binding proteins
    7. Conclusions and perspectives
    Acknowledgements
    References

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    作者:Xiao, Shi, Chye, Mee-Len 来源:Elsevier 发布时间:2011年07月13日